The Diet-Multiple Sclerosis Connection: Oxidative Stress and Emerging Mechanisms - PubMed
5 days ago
- #Oxidative Stress
- #Multiple Sclerosis
- #Diet
- Multiple sclerosis (MS) is an autoimmune neuroinflammatory disease causing myelin degeneration and progressive disability.
- Oxidative stress plays a crucial role in MS pathogenesis and progression.
- Nuclear factor erythroid 2-related factor 2 (Nrf2) is a master regulator of antioxidant mechanisms, and its upregulation is beneficial in MS.
- Diet is a promising non-pharmacological strategy to modulate Nrf2 and improve MS outcomes.
- Mediterranean, ketogenic, and Paleolithic diets contain natural compounds that enhance Nrf2 activity and show benefits in preclinical MS models.
- Emerging mechanisms like epigenetic regulation and G-quadruplexes may offer new therapeutic targets for MS.
- Nrf2 modulation by diet has preclinical and limited clinical support, but targeting G-quadruplexes remains speculative.
- Epigenetic mechanisms and G-quadruplexes could be innovative targets for dietary compounds in MS therapy.