Resectable Stage Early-Onset Biliary Tract Cancer: Survival and Prognostic Scoring (EOB-RS and EOB-OS) in Turkish Patients (TOG/GI-SAFRADJU-2502-EO) - PubMed
5 hours ago
- #Early-Onset Cancer
- #Biliary Tract Cancer
- #Prognostic Scoring
- The study focused on early-onset biliary tract cancers (EOBTCs), defined as diagnosis under age 50, in Turkish patients with resectable stage disease.
- Among 617 patients, 12.6% had EOBTC. EOBTC patients had a significantly higher rate of R1 resection (37.1% vs. 25.7%) compared to non-EOBTC patients.
- Recurrence-free survival (RFS) and overall survival (OS) were similar between EOBTC and non-EOBTC groups when patients received adjuvant chemotherapy.
- For EOBTC patients, R1 resection and high CA19-9 levels were associated with shorter RFS, while gallbladder localization and high CA19-9 were linked to shorter OS.
- Prognostic risk scores (EOB-RS for RFS and EOB-OS for OS) were developed, each with three risk ranks that significantly stratified patient outcomes.