The Molecular Mechanisms of Metformin's Action on Blood Lipid Profile in Diabetic Patients - PubMed
4 hours ago
- #Diabetes
- #Lipid Metabolism
- #Metformin
- Metformin improves blood lipid profile in diabetic patients by lowering total cholesterol, LDL-cholesterol, and triacylglycerol, while increasing HDL-cholesterol.
- Key mechanisms include AMPK activation, which inhibits lipogenesis and cholesterol synthesis, and promotes fatty acid oxidation.
- Other actions involve promoting VLDL-TAG clearance, inhibiting Nrf2, PCSK9, and lipogenic enzyme gene expression, downregulating ChREBP, and affecting ANGPTL3.
- Metformin's modulation of lipid metabolism contributes to reduced cardiovascular risk in type 2 diabetes patients.