The risk of osteoporosis in COPD: An analysis of sex differences and mediating effects based on NHANES - PubMed
5 days ago
- #COPD
- #NHANES
- #Osteoporosis
- COPD and osteoporosis often co-occur due to shared risk factors like aging, smoking, and systemic inflammation.
- The study included 8,274 participants aged ≥50 years from NHANES cycles 2005-2018.
- COPD was significantly associated with a higher risk of osteoporosis (OR = 2.24, P < 0.001).
- A stronger association was observed in males (adjusted OR = 4.85) compared to females (adjusted OR = 1.86).
- Prednisone use and sleep problems partially mediated the association between COPD and osteoporosis.
- Vitamin D levels did not show meaningful mediation in the association.
- Sensitivity analyses confirmed COPD's association with lower Bone Mineral Density (BMD).
- The study highlights the importance of integrated bone health management in COPD patients, with attention to sex-specific risks and modifiable factors.