Megakaryocyte and platelet thrombospondin-1 regulates matrix remodeling by stabilizing basement membrane COL6A1 in lung injury - PubMed
5 hours ago
- #lung injury
- #thrombospondin-1
- #extracellular matrix
- Megakaryocytes and platelets (Mgk/plt) play a role in stabilizing the extracellular matrix (ECM) in lung injury through thrombospondin-1 (TSP1).
- Mgk/plt-specific Thbs1 knockout (cKO) mice show increased alveolar barrier disruption and neutrophil-mediated injury.
- TSP1 from Mgk/plt protects the basement membrane protein COL6A1 from degradation during lung injury.
- cKO mice exhibit ECM reorganization, reduced COL6A1, and increased Mgk accumulation in areas of alveolar leak.
- Mgk/plt-derived TSP1 is crucial for matrix stabilization and regulating injury severity.