Low- and no-calorie sweeteners and beverages and their associated health outcomes: an umbrella review of systematic reviews and meta-analyses - PubMed
5 hours ago
- #health outcomes
- #artificial sweeteners
- #meta-analysis
- Umbrella review evaluates health outcomes of low- and no-calorie sweeteners (LNCSs) and beverages from observational studies and RCTs.
- Observational studies link higher non-sugar sweetener (NSS) intake to increased risks of overweight, metabolic syndrome, type 2 diabetes, and hypertension.
- RCTs show NSS consumption reduces body weight in overweight or obese populations with high certainty of evidence.
- Study includes 29 meta-analyses covering over 50 million participants, with most rated high quality using AMSTAR 2 tool.
- Conclusions indicate LNCSs are associated with both potential health risks and modest benefits.