Human monoclonal antibodies isolated after seasonal vaccination broadly neutralize antigenically drifted influenza B viruses - PubMed
5 hours ago
- #monoclonal antibodies
- #antigenic drift
- #influenza B virus
- Human monoclonal antibodies CAV-CF22 and CAV-CH76 were isolated after seasonal vaccination.
- These antibodies broadly neutralize antigenically drifted influenza B viruses (IBVs) from both Victoria and Yamagata lineages.
- Post-2019 Victoria-lineage IBVs escaped neutralization by previously identified broadly neutralizing monoclonal antibodies (bnAbs) due to the K136E mutation in hemagglutinin (HA).
- CAV-CF22 and CAV-CH76 bypass K136E by inserting HCDR3 into the receptor-binding site (RBS), mimicking sialic acid.
- Structural and phylogenetic analysis highlights the conservation of epitope residues, explaining the antibodies' broad neutralizing activity.
- The findings inform future antibody and vaccine designs resilient to IBV antigenic drift.