Ferro-Aging: A Novel Paradigm Linking Iron Overload, Lipid Peroxidation and Cellular Senescence - PubMed
5 hours ago
- #Iron Overload
- #Cellular Senescence
- #Aging
- Iron overload in aging acts as an amplifier, driving oxidative stress, mitochondrial damage, and inflammation.
- Ferro-aging links iron overload to lipid peroxidation, inducing cellular senescence and ferroptosis in a positive feedback loop.
- Senescent cells resist ferroptosis, leading to persistent accumulation and chronic inflammation in tissues.
- The ferro-aging paradigm contributes to age-related diseases in nervous, cardiovascular, metabolic, and skeletal systems.
- Targeting iron homeostasis, lipid peroxidation, senescence, and mitochondria offers potential anti-aging interventions.