Clinically distinct metabotypes of pediatric MASLD identified through unsupervised clustering of NASH CRN data - PubMed
5 hours ago
- #pediatric MASLD
- #metabotypes
- #NASH CRN
- Three distinct metabotypes of pediatric MASLD were identified through unsupervised clustering: early-mild (49.4%), cardiometabolic (36.8%), and inflammatory-fibrotic (13.8%).
- The inflammatory-fibrotic group showed alterations in tryptophan metabolism, particularly elevated kynurenine pathway metabolites, correlated with fibrosis stage.
- The cardiometabolic group exhibited greater enrichment in branched-chain amino acid degradation, butanoate, and purine metabolism.
- The study provides a framework for targeted interventions in pediatric MASLD, though validation in independent cohorts is needed.
- Competing interests and research grants from various pharmaceutical companies were disclosed by some authors.