Smart nano-assembly from traditional Chinese medicine: manganese-enhanced polysaccharide platform for orchestrated cancer chemo-immunotherapy - PubMed
5 hours ago
- #Traditional Chinese Medicine
- #Nanomedicine
- #Cancer Therapy
- Development of a pH-responsive nano-assembly (LUT@POP-FH-Mn) integrating Polygonatum odoratum polysaccharide (POP), luteolin (LUT), and manganese ions (Mn2+) for cancer therapy.
- The system combines chemotherapy, chemodynamic therapy (CDT), and immunotherapy, showing enhanced efficacy with an IC50 reduction to 0.22 μg/mL (A549) and 0.98 μg/mL (HeLa).
- Mechanism involves triple synergy: LUT-induced oxidative stress and apoptosis, Mn2+-mediated Fenton-like reactions for lipid peroxidation, and POP-Mn2+ activation of dendritic cells to initiate antitumor immunity.
- Demonstrates the potential of natural product-based nanomedicine for modernizing traditional Chinese medicine in combined cancer therapy.