Clinical characteristics and surgical outcomes of Rasmussen encephalitis: A retrospective dual-center cohort study - PubMed
5 hours ago
- #Rasmussen encephalitis
- #hemispherectomy
- #epilepsy surgery
- Rasmussen encephalitis (RE) is a rare disorder causing drug-resistant epilepsy.
- Hemispheric surgery is an established treatment for RE, with 79% of patients achieving seizure-free status post-surgery.
- Hemispheric disconnection showed superior seizure control (92%) compared to anatomic (67%) or functional hemispherectomy (57%).
- Stable gross motor function was achieved in 94% of patients, but 64% experienced worsening fine motor skills.
- Factors associated with seizure persistence include generalized seizures, contralateral MRI abnormalities, contralateral EEG discharges, and type of hemispheric surgery.
- Postoperative seizure-free status and baseline Motricity Index (MI) predicted overall motor stability.
- Fine motor stability was related to EPC duration, preoperative immunotherapy, and baseline MACS.
- Early surgery, attention to contralateral abnormalities, and preoperative immunotherapy may improve outcomes.