Hypoxic-inflammatory preconditioning endows BMSC-derived appoptotic extracellular vesicles with potent efficacy against IVDD via cell activation and mitochondrial homeostasis regulation - PubMed
4 hours ago
- #IVDD
- #ApoEVs
- #Mitochondrial homeostasis
- Hypoxic-inflammatory preconditioning enhances BMSC-derived apoptotic extracellular vesicles (ApoEVs) for treating intervertebral disc degeneration (IVDD).
- IVDD is a major cause of chronic low back pain, driven by nucleus pulposus cell (NPC) senescence linked to mitochondrial homeostasis.
- ApoEVs from mesenchymal stem cells (MSCs) show promise in tissue regeneration, especially when pretreated under hypoxic-inflammatory conditions (I-ApoEVs).
- I-ApoEVs significantly improve NPC viability and mitochondrial function compared to hypoxia-only pretreated ApoEVs.
- The study provides evidence for optimizing ApoEV-based therapies for IVDD by regulating mitochondrial homeostasis.