Cilia beating of ependymal cells regulates adult neural stem cell quiescence via mechanical forces mediated by PKD1/2-TRPM3 - PubMed
3 hours ago
- #cilia beating
- #mechanosensation
- #neural stem cells
- Transient inhibition of cilia beating in ependymal cells leads to activation of neural stem cells (NSCs).
- Mechanical forces from cilia beating promote NSC quiescence through PKD1/2-TRPM3-mediated calcium signaling.
- Genetic deletion of TRPM3 or PKD1/2 in NSCs mimics the effects of inhibiting cilia beating.
- Pharmacological activation of TRPM3 restores NSC quiescence even without cilia beating.