Small molecule-constrained paratope mimetic bicyclic peptides as potent inhibitors of group 1 and 2 influenza A virus hemagglutinins - PubMed
5 hours ago
- #drug design
- #peptide inhibitors
- #influenza
- Development of small molecule-constrained paratope mimetic bicyclic peptides as potent inhibitors for influenza A virus hemagglutinins (HA).
- Innovative CLIPS-based approach merges antibody and small molecule features to target both group 1 and group 2 HAs.
- Peptides exhibit cross-reactivity in binding and neutralizing various influenza strains (H1N1, H5N1, H7N3).
- Crystal structure confirms peptide mimics the binding mode of the parent antibody FI6v3 to the conserved HA stem epitope.
- Potential for development of pan-influenza therapeutics targeting both group 1 and group 2 influenza A viruses.