Cellular survivorship bias as a mechanistic driver of muscle stem cell aging - PubMed
3 months ago
- #aging
- #muscle regeneration
- #stem cells
- Aging leads to a decline in tissue repair and regeneration, particularly in skeletal muscle.
- Muscle stem cells (MuSCs) show impaired function with age, affecting muscle regeneration.
- A cellular survivorship bias in aging MuSCs prioritizes survival over functionality.
- Aged MuSCs increase expression of NDRG1, a tumor suppressor, which suppresses the mTOR pathway.
- This suppression enhances long-term survival of MuSCs but delays their activation and muscle regeneration.
- The trade-off favors stem cell survival over immediate regenerative capacity, leading to delayed muscle repair.