Careful ventilation in acute respiratory distress syndrome: the protocol of the CAVIARDS international multicentre randomised basket trial - PubMed
5 hours ago
- #Mechanical Ventilation
- #Randomised Controlled Trial
- #ARDS
- The CAVIARDS trial is an international multicentre randomised controlled trial focusing on careful ventilation strategies in ARDS.
- The study aims to individualise ventilator settings based on lung recruitability, distending pressure, and respiratory drive to improve ARDS outcomes.
- 740 patients with moderate-to-severe ARDS, including those induced by COVID-19, will be randomised into two groups for different ventilation strategies.
- Primary outcome is all-cause mortality at day 60, with secondary outcomes including duration of mechanical ventilation, ICU stay, and organ dysfunction.
- Ethics approval has been obtained from multiple international centres, and findings will be disseminated in peer-reviewed journals and conferences.