Gut microbiome composition and functional potential associate with incident type 2 diabetes in 4,685 adults from a Swedish prospective cohort - PubMed
2 hours ago
- #prospective cohort
- #type 2 diabetes
- #gut microbiome
- Six species, including Desulfovibrio piger and Akkermansia muciniphila, are associated with an increased risk of incident type 2 diabetes.
- Three species, including Erysipelotrichaceae bacterium and Coprococcus catus, show protective effects against type 2 diabetes.
- Three gut metabolic modules—asparagine degradation (higher risk), mannose degradation, and the non-oxidative pentose phosphate pathway (lower risk)—are linked to diabetes development.
- Dietary fiber modifies the association of Akkermansia muciniphila with diabetes risk, indicating diet-dependent microbiome effects.
- The study uses shotgun metagenomic data from 4,685 Swedish adults, followed for a median of 5.3 years, with 383 incident diabetes cases.