Accuracy of clinical diagnosis in neurodegenerative diseases - a study of 455 autopsy cases - PubMed
2 days ago
- #neurodegenerative diseases
- #neuropathology
- #clinical diagnosis
- Study examines the accuracy of clinical diagnoses in neurodegenerative diseases using neuropathological data from 455 autopsy cases.
- Clinical sensitivity varied widely (0-100%) while specificity was consistently high (89.5-100%) across nine neurodegenerative diseases.
- Accuracy was very good (AUC > 0.9) for Huntington's disease, motor neuron disease, and multiple system atrophy.
- Moderate to limited accuracy was found for frontotemporal dementia, corticobasal degeneration, and argyrophilic grain disease.
- Improving diagnostic sensitivity is crucial for early patient identification, especially with emerging disease-modifying therapies.
- Development of reliable molecular biomarkers is essential for better clinical diagnosis of neurodegenerative diseases.