Testicular aging revisited: Current understanding of mechanisms and emerging interventions - PubMed
6 hours ago
- #Male reproductive aging
- #Testicular aging mechanisms
- #Fertility interventions
- Testicular aging involves progressive deterioration in spermatogenesis, hormonal imbalance, and increased risk of infertility and genetic disorders.
- Key mechanisms include mitochondrial dysfunction, oxidative stress, DNA damage, autophagy impairment, chronic inflammation, cellular senescence, and dysregulated apoptosis.
- Aging affects Sertoli and Leydig cell function, disrupting the blood-testis barrier, impairing steroidogenesis, and compromising germ cell support, leading to reduced sperm quantity and quality.
- Emerging interventions target these pathways with antioxidants, DNA repair enhancers, autophagy modulators, and anti-inflammatory compounds to delay aging and preserve fertility.