ROS-Responsive Spatiotemporal Delivery System Targeting Tendon-Bone Interface for Rotator Cuff Repair - PubMed
11 hours ago
- #Oxidative Stress
- #Biomaterials
- #Rotator Cuff Repair
- A ROS-responsive spatiotemporal delivery system (CMMKT) was developed for rotator cuff repair.
- CMMKT targets the tendon-bone interface (TBI) by combining inflammation control and fibrocartilage regeneration.
- The system uses ROS-responsive polymers to release magnesium ions (Mg2+) and kartogenin (KGN).
- Coated with fibrochondrocyte cell membranes, CMMKT enhances spatial specificity for fibrocartilage cells.
- In vitro, CMMKT promotes BMSC migration, proliferation, and differentiation while reducing apoptosis and increasing M2 macrophages.
- In a rat model, CMMKT improved collagen maturity, biomechanical strength, and fibrochondrocyte matrix deposition.
- Transcriptomic and metabolomic analyses showed reduced oxidative stress and activated anabolic pathways in fibrocartilage.
- CMMKT integrates immunomodulation and targeted regeneration for effective TBI repair.