Shear stress-induced Piezo1 activates CD99L2 to facilitate the initiation of blood circulation - PubMed
6 hours ago
- #erythrocyte adhesion
- #CD99L2
- #Piezo1
- Shear stress activates Piezo1 signaling, which induces CD99L2 expression in primitive erythrocytes during a specific developmental window.
- CD99L2 is essential for erythrocytes to detach from the endothelium and enter the bloodstream, as its loss leads to erythrocyte retention, impaired maturation, and hemolytic anemia.
- Mechanistically, CD99L2 binds and anchors β-catenin at the membrane, preventing its nuclear translocation and the subsequent activation of Rap1 signaling and adhesion molecule expression.
- This pathway, conserved in zebrafish and mouse models, couples hemodynamic forces to erythrocyte adhesion control, facilitating the initiation of blood circulation.