LFA-1 interaction with GBP-130 on Plasmodium falciparum-infected red blood cells mediates NK cell activation and parasite control - PubMed
2 hours ago
- #NK cell activation
- #host-parasite interaction
- #malaria immunity
- LFA-1 integrin on NK cells interacts with PfGBP-130 on Plasmodium falciparum-infected red blood cells (iRBCs).
- PfGBP-130 is identified as the parasite ligand for LFA-1's I-domain, binding stage-specifically to iRBCs.
- Recombinant PfGBP-130 binds to NK and THP-1 cells via LFA-1, promoting NK cell activation and degranulation.
- PfGBP-130 facilitates contact-dependent killing of iRBCs by NK cells, enhancing parasite control.
- Neutralizing antibodies against PfGBP-130 impair NK cell responses, highlighting its role in malaria immunity.
- This discovery offers insights into NK-mediated immunity and potential host-directed interventions for malaria.