Neuropsychiatric symptoms in preclinical and clinically manifest dementia: clusters and their health determinants - PubMed
4 days ago
- #mental health
- #dementia
- #neuropsychiatric symptoms
- Neuropsychiatric symptoms (NPS) are common in dementia, but their patterns in preclinical stages remain unclear.
- The study identified four NPS clusters: minimal NPS, depression-anxiety-apathy, depression-anxiety, and delusions-agitation-irritability.
- Cluster profiles differed between dementia and dementia-free groups.
- Specific clinical and metabolic factors like lipid abnormalities, glycemic control, thyroid dysfunction, and underweight status were associated with NPS clusters.
- Distinct NPS patterns exist across the dementia continuum, differing in demographic, cognitive, functional, and metabolic profiles.
- NPS may precede cognitive decline and represent syndromic entities with diagnostic relevance.
- Multidimensional, personalized approaches are needed for managing NPS in dementia.