Aptamer-Based Discovery of Neuropilin-2 as a Potential Biomarker and Therapeutic Target in Bladder Cancer - PubMed
6 hours ago
- #bladder cancer
- #aptamer
- #NRP2
- An aptamer named ss2-2 was developed through Cell-SELEX and optimization, showing strong affinity and specificity for bladder cancer cells.
- The molecular target of aptamer ss2-2 was identified as neuropilin-2 (NRP2), a transmembrane glycoprotein, validated through knockdown and binding studies.
- NRP2 expression was significantly elevated in bladder cancer tissues, correlating with advanced tumor stage, and its knockdown inhibited cancer cell proliferation, migration, and affected key signaling pathways.