Herpes simplex virus-1 induces complement-mediated microglial phagocytosis of synapses in murine primary brain cultures and tissues - PubMed
a day ago
- #HSV-1
- #Complement Cascade
- #Neurodegeneration
- HSV-1 infection upregulates the classical complement cascade in murine brain cultures and tissues.
- HSV-1 induces microglial phagocytosis of synapses, partially prevented by complement inhibition.
- Virus-triggered synaptic damage involves complement-dependent microglial pruning.
- Decreased spine density and synaptic transmission in CA1 neurons are rescued by C3 neutralization.
- HSV-1 contributes to neurodegeneration via aberrant complement activation and synaptic loss.
- Findings support HSV-1 as a risk factor for Alzheimer’s disease (AD).