Invasion of gut-derived escherichia coli extracellular vesicles exacerbates myocardial ischemia/reperfusion injury - PubMed
5 hours ago
- #Inflammation
- #Gut-heart axis
- #Extracellular vesicles
- Gut-derived Escherichia coli extracellular vesicles (EVs) worsen myocardial ischemia/reperfusion injury.
- Bacterial EVs are overlooked but play key roles in pathological processes, including inflammation.
- Myocardial ischemia-reperfusion injury enhances invasion of gut-derived bacterial EVs in mice and humans.
- E. coli EVs correlate with LPS in blood, acting as carriers for LPS translocation.
- These EVs exacerbate systemic and local inflammatory cell mobilization, worsening heart damage.
- Glucagon-like peptide-2 (GLP-2) can reduce inflammation and injury by inhibiting E. coli EV translocation.
- First study confirming gut-derived EVs' impact on myocardial ischemia-reperfusion injury.
- Findings provide insights into the gut-heart axis and potential GLP-2 therapy for cardiovascular diseases.