Selenium nanoparticle-loaded microneedle patches promote diabetic oral ulcer healing by regulating the inflammatory microenvironment through upregulation of SELENBP1-mediated mitophagy - PubMed
6 hours ago
- #Nanoparticle Therapy
- #Diabetic Wound Healing
- #Mitophagy Regulation
- Selenium nanoparticle-loaded microneedle patches (Ser-SeNPs@MN) promote healing of diabetic oral ulcers by targeting selenium deficiency and mitochondrial damage.
- The patches upregulate SELENBP1 expression, enhancing selenoprotein production and activating PINK1/Parkin-mediated mitophagy to restore mitochondrial function.
- This reduces inflammation, promotes M2 macrophage polarization, and accelerates wound closure, collagen deposition, and angiogenesis in diabetic rat models.