African swine fever virus pE199L, as a mitophagy receptor, suppresses antiviral innate immunity to promote viral replication - PubMed
5 hours ago
- #innate immunity
- #African swine fever virus
- #mitophagy
- The African swine fever virus (ASFV) pE199L protein acts as a mitophagy receptor to suppress antiviral innate immunity and promote viral replication.
- pE199L localizes to mitochondria via its C-terminal hydrophobic domain and induces mitochondrial fission by promoting DNM1L/Drp1 phosphorylation.
- It contains three LC3-interacting regions (LIRs) that mediate mitophagic degradation of key immune adaptors TBK1 and MAVS, inhibiting type I interferon production.
- This mechanism represents a novel immune evasion strategy and a potential target for antiviral vaccine development.