Integrative clinical and genomic analyses reveal a causal role of GPNMB in the bone-brain axis of Parkinson's disease - PubMed
7 hours ago
- #Parkinson's disease
- #bone-brain axis
- #GPNMB
- GPNMB levels are significantly elevated in Parkinson's disease (PD) patients and show a linear association with PD risk.
- Higher GPNMB levels correlate with worse cognitive performance and clinical severity, while higher SOST levels are associated with milder symptoms.
- Genetic analyses support a causal and colocalized relationship between GPNMB and PD.
- Total coxa BMD and T-score were lower in PD, but not statistically significant.
- An 'n-shaped' association was found between total coxa T-score and both PD and GPNMB levels.
- GPNMB may mediate the bone-brain axis connecting bone mineral density (BMD) with PD susceptibility.