Glucosamine as a regulator of O-GlcNAc signaling: linking metabolism to disease pathogenesis - PubMed
7 hours ago
- #Glucosamine
- #Metabolic Regulation
- #O-GlcNAcylation
- Glucosamine is a naturally occurring amino sugar used as a dietary supplement for osteoarthritis and joint pain.
- It is metabolized through the hexosamine biosynthetic pathway (HBP) to produce UDP-GlcNAc, a substrate for O-GlcNAc modification.
- Glucosamine modulates HBP flux and O-GlcNAcylation, impacting cellular signaling, metabolic regulation, and inflammatory responses.
- Its effects extend beyond musculoskeletal health to diseases like rheumatoid arthritis, diabetes, obesity, neurodegenerative disorders, and cancer.
- Glucosamine's role as a metabolic regulator of O-GlcNAc cycling is underexplored despite its clinical use.
- The review highlights glucosamine's potential as a therapeutic modulator of inflammation and systemic pathology.