Effectiveness of Systemic Treatments for Atopic Dermatitis in the Head-and-Neck-Area: A Systematic Review and Meta-analysis - PubMed
3 days ago
- #Systemic Treatments
- #Atopic Dermatitis
- #Head-and-Neck Area
- Systemic treatments for atopic dermatitis (AD) in the head-and-neck area were evaluated through a systematic review and meta-analysis.
- The study focused on the effectiveness of biologics and Janus kinase inhibitors (JAKis) in treating AD in the head-and-neck region.
- Mean reductions in Eczema Area and Severity Index for the head-and-neck region (EASI-HN) after 16 weeks ranged from 59% to 85% across different treatments.
- Proportion of patients achieving 75% improvement in EASI-HN (EASI75-HN) after 16 weeks varied from 20% to 66%.
- Upadacitinib and dupilumab showed significant effectiveness, with upadacitinib 30 mg once daily achieving an 80% reduction in EASI-HN and 66% in EASI75-HN.
- Limited and non-comparable evidence was found for conventional systemic therapies like cyclosporine and methotrexate.
- The study concluded that biologics and JAKis are effective for AD in the head-and-neck region, with responses comparable to other body areas.
- Further research is needed for direct comparisons between therapies.