Exercise and nutrition as epigenetic regulators of gene expression: an exploratory scoping review with bibliometric analysis - PubMed
6 hours ago
- #scoping-review
- #epigenetics
- #exercise-nutrition
- Combined exercise and nutrition interventions show multi-layered epigenetic changes, including DNA methylation, histone modifications, and non-coding RNAs, with potential synergistic or additive effects.
- Included studies (17 with 1,568 participants, predominantly randomized controlled trials) link epigenetic changes to improvements in metabolic health, muscular adaptability, inflammation modulation, and aging markers.
- Bibliometric analysis reveals research concentration in intervention strategies, mechanistic exploration, and health outcomes, with emerging interest in tissue-specific responses and epigenetic clocks.
- Current evidence is exploratory and heterogeneous; future research needs standardized epigenetic assessments, longitudinal multi-tissue studies, multi-omics integration, and enhanced international collaboration.