Incidence, Predictors, Management, and Clinical Impact of Major Bleeding Following Left Atrial Appendage Occlusion: The Amulet IDE Randomized Clinical Trial - PubMed
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- #left atrial appendage occlusion
- #clinical trial
- #major bleeding
- Major bleeding occurred in 18.1% of patients over 5 years after left atrial appendage occlusion, with an annualized rate of 5.9%.
- Risk of major bleeding was highest within the first 6 months post-procedure (20.5% per year) and then decreased to 3.9% per year through 5 years.
- Independent predictors of major bleeding included older age, female sex, diabetes, prior major bleeding, and kidney disease.
- Most major bleeding events were nonprocedural (88.8%), with gastrointestinal bleeding being the most common type.
- Patients with major bleeding had significantly higher rates of stroke, cardiovascular death, and all-cause mortality compared to those without major bleeding.
- At the time of first major bleeding event, 47.1% of patients were not receiving antithrombotic therapy.