Copper Homeostasis and Cuproptosis in Neurological Disorders - PubMed
12 hours ago
- #copper homeostasis
- #neurological disorders
- #cuproptosis
- Neurological disorders like Alzheimer's and Parkinson's disease are increasing globally, linked to genetic, environmental, and metabolic factors.
- Copper homeostasis imbalance is implicated in neurological diseases, with overload causing oxidative stress and deficiency disrupting enzyme functions.
- Cuproptosis, a newly identified form of programmed cell death, involves lipoylated protein aggregation and Fe-S cluster protein loss.
- Copper metabolism abnormalities play roles in diseases such as Huntington's, ALS, multiple sclerosis, Wilson's disease, Menkes disease, and stroke.
- Copper-regulating drugs show therapeutic potential but face limitations in development for neurological disorders.