Reprogramming of stroma-derived chemokine networks drives the loss of tissue organization in nodal B cell lymphoma - PubMed
5 hours ago
- #stromal remodeling
- #chemokine networks
- #lymphoma
- Lymph node (LN) function relies on organized spatial cell arrangements, but the principles of LN architecture in health and disease are not well understood.
- Single-cell and spatial mapping revealed stromal cell-driven chemokine networks that maintain lymphocyte zonation in human LNs.
- In follicular lymphoma (FL) and diffuse large B-cell lymphoma (DLBCL), tumor-reactive T cells trigger stromal remodeling, disrupting homeostatic chemokine gradients and leading to tissue disorganization.
- Loss of homeostatic chemokines correlates with worse patient survival, indicating architectural disruption as a critical factor in lymphomagenesis.
- The study highlights how lymphoma-induced microenvironmental reprogramming contributes to the breakdown of LN organization.