The oncogenome of the domestic cat - PubMed
3 days ago
- #Oncogenome
- #Domestic Cat
- #Comparative Oncology
- Cancer is a common cause of morbidity and mortality in domestic cats.
- Targeted sequencing of 493 feline tumor-normal tissue pairs from 13 tumor types was performed.
- The study focused on feline orthologs of ~1000 human cancer genes.
- TP53 was the most frequently mutated gene in domestic cat tumors.
- Recurrent copy number alterations included loss of PTEN or FAS and gain of MYC.
- 31 driver genes, mutational signatures, viral sequences, and tumor-predisposing germline variants were identified.
- The study confirms the domestic cat as a valuable model for comparative oncology studies.
- Findings align with a 'One Medicine' approach, identifying potentially actionable mutations.