Isoprenaline Alleviates Diabetic Kidney Disease via Multi-Target Inhibition of the cGAS-STING Pathway - PubMed
4 days ago
- #Isoprenaline
- #cGAS-STING pathway
- #Diabetic kidney disease
- Isoprenaline (ISO) alleviates diabetic kidney disease (DKD) by inhibiting the cGAS-STING pathway.
- ISO treatment in diabetic mice improved glomerulosclerosis, reduced podocyte injury, and suppressed renal inflammation.
- Network pharmacology and molecular docking suggest ISO interacts with multiple targets (AKT1, SRC, GSK3β, EGFR) involved in cGAS-STING regulation.
- The study provides new insights into therapeutic development for DKD by targeting the cGAS-STING pathway.