Glucagon-like peptide-1 receptor agonists and rotator cuff disease: a scoping review - PubMed
5 hours ago
- #scoping review
- #rotator cuff disease
- #GLP-1 receptor agonists
- GLP-1 receptor agonists are used for obesity and type 2 diabetes, which are linked to poor rotator cuff healing.
- A scoping review found no association between preoperative GLP-1RA use and increased post-surgery complications after rotator cuff repair.
- GLP-1RA use was associated with a higher incidence of atraumatic rotator cuff tears and subsequent repairs.
- Preclinical studies showed that liraglutide improved tendon-bone interface strength, reduced fatty infiltration, and decreased cellular stress in rotator cuff repair models.
- More high-quality prospective studies are needed to clarify GLP-1RA effects on rotator cuff disease.