A Morphology-Driven Cascade Delivery of Antigens for Potent T Cell Immunity - PubMed
4 hours ago
- #nanoparticle morphology
- #vaccine delivery
- #cellular immunity
- Engineered mesoporous silica nanoparticles with long-spiked morphology (SNL) enhance antigen delivery and antigen-presenting cell (APC) activation.
- SNL nanoparticles boost Piezo1-mediated calcium influx, promoting dendritic cell activation and improving antigen trafficking to the endoplasmic reticulum (ER) for cross-presentation.
- Co-loading antigens with the STING agonist 2'3'-cGAMP in SNL triggers synergistic immune activation and robust CD8+ T cell responses.
- This approach delays tumor progression in lymphoma and cervical cancer models and provides cross-protective immunity in a SARS-CoV-2 vaccination model.
- Nanoparticle morphology is a critical design parameter for precise intracellular delivery and advancing next-generation vaccine development.