Prevalence, risk factors, and early prediction of refractory pneumonia caused by Mycoplasma pneumoniae in children: a systematic review and meta-analysis - PubMed
10 hours ago
- #Pneumonia
- #Pediatrics
- #Meta-analysis
- Refractory Mycoplasma pneumoniae pneumonia (rMPP) prevalence in children is 37.8%, with significant temporal variation.
- Key risk factors include elevated lactate dehydrogenase, C-reactive protein, procalcitonin, interleukin-6, neutrophil count, pleural effusion, mucus plugs, and older age.
- Eleven prediction models demonstrated high accuracy with ROC-AUCs of 0.913 (training) and 0.895 (validation).
- The prevalence of rMPP has increased markedly since the COVID-19 pandemic.
- Key biomarkers and clinical features facilitate early risk stratification.
- Validated predictive models improve clinical decision-making.