Antibody repertoire associated with clinically diverse presentations of pediatric SARS-CoV-2 infection - PubMed
6 hours ago
- #Pediatric SARS-CoV-2
- #Autoantibodies
- #MIS-C
- Pediatric SARS-CoV-2 infection shows diverse clinical presentations, from asymptomatic to severe COVID-19 and MIS-C.
- All infection manifestations increase autoantibody production compared to uninfected subjects, suggesting immune dysregulation.
- Autoantibody patterns vary subtly among groups, with some linked to mild symptoms and others to severe disease.
- MIS-C and severe COVID-19 subjects show elevated autoreactive antibodies against thyroperoxidase, IL-13, and IFN-epsilon.
- Differences in IgG abundance (mainly IgG1) are noted between MIS-C and severe COVID-19, but not in Fc-mediated effector functions.
- The antibody repertoire in children varies with clinical presentation, and MIS-C may involve abnormal antibody function.