Fibroblast Growth Factor 23 as a Prognostic Biomarker in Post-Myocardial Infarction Outcomes: Influence of Renal Function and Its Modulation by Klotho - PubMed
7 days ago
- #Myocardial Infarction
- #FGF23
- #Klotho
- Elevated FGF23 and decreased Klotho levels are linked to cardiovascular and renal diseases.
- FGF23 levels inversely correlate with Klotho in post-MI patients.
- High FGF23 is associated with ST-segment-elevation MI, cardiac dysfunction, and higher mortality risk.
- Klotho levels are reduced in ST-segment-elevation MI but do not correlate with mortality.
- Ischemic injury upregulates FGF23 expression in cardiac tissue.
- Klotho modulates FGF23-driven processes but does not inhibit FGF23 overexpression post-MI.
- FGF23 is a potential prognostic biomarker for mortality and cardiac dysfunction post-MI.
- Klotho has cardioprotective properties but is not a reliable mortality predictor post-MI.