Higher Colonic Tissue Drug Concentrations of Subcutaneous Compared to Intravenous Administration of Infliximab Therapy in Patients With Inflammatory Bowel Disease - PubMed
6 hours ago
- #Infliximab
- #Therapeutic Drug Monitoring
- #Inflammatory Bowel Disease
- Subcutaneous (SC) infliximab achieved significantly higher serum and colonic tissue concentrations compared to intravenous (IV) administration in IBD patients.
- Colonic tissue infliximab levels were better predictors of sustained clinical remission than serum levels, with optimal thresholds of 17 μg/g for tissue and 14.5 μg/mL for serum.
- Tissue drug concentrations were higher in patients with mild-moderate endoscopic activity versus no active disease, suggesting tissue levels may guide therapeutic drug monitoring.