Estimation of positron emission tomography amyloid load and related biomarkers in Alzheimer's disease using evoked potential tomography EEG: development and internal validation in a cross-sectional co
5 hours ago
- #Biomarkers
- #Alzheimer's disease
- #Electroencephalography
- Evoked Potential Tomography (EPT), an EEG-based method, was developed to estimate Alzheimer's disease biomarkers.
- EPT uses a novel visual evoked potential protocol and an automated pipeline for EEG preprocessing and regression modeling.
- Key biomarkers estimated include PET-amyloid SUVR, CSF p-tau181, FCSRT, and MMSE scores.
- Regression models showed strong correlations (r=0.8-0.94) between predicted and true biomarker values in dementia participants.
- In an external cohort, PET-amyloid SUVR predictions remained significantly associated with true values (r=0.60).
- EPT shows potential as a sensitive, non-invasive method for estimating AD biomarkers, with further validation ongoing.