Tumor Organoid and Microenvironment Cocultures: Implications for Basic and Translational Cancer Research - PubMed
5 hours ago
- #tumor microenvironment
- #organoids
- #cancer research
- Organoids are 3D cellular models that replicate the complexity of organs and tissues, offering a platform for cancer research.
- The tumor microenvironment (TME) is crucial in tumor evolution and therapy resistance, making TME-targeting therapies a key area in cancer treatment.
- Current organoid coculture methods include direct coculture, air-liquid interface, microfluidics, and 3D bioprinting to mimic multicellular interactions in TME.
- These models help understand fundamental cancer mechanisms and evaluate therapies like antibody-drug conjugates and immunotherapy.
- By mimicking in vivo conditions, organoid cocultures improve therapeutic outcome predictions and support precision medicine development in oncology.