Si-Ni-San alleviates depression-like behavior via regulating the gut microbiota-tryptophan metabolism-AhR/NF-κB pathway axis - PubMed
5 hours ago
- #Depression
- #Gut Microbiota
- #Neuroinflammation
- Si-Ni-San (SNS), a classic herbal formula, alleviates depression-like behavior in mice by modulating gut microbiota and tryptophan metabolism.
- SNS increases levels of gut microbiome-derived indole-3-acetic acid (IAA) by enriching Lactobacillus, which then activates the aryl hydrocarbon receptor (AhR).
- Activation of AhR by IAA inhibits the NF-κB pathway, reducing neuroinflammation and producing antidepressant effects, as confirmed by oral IAA supplementation.