Irisin ameliorates obesity and insulin resistance via adipose tissue IL-33 and regulatory T cells - PubMed
21 hours ago
- #obesity
- #irisin
- #IL-33
- Irisin, an exercise-induced myokine, improves obesity and insulin resistance in mice.
- Irisin increases IL-33 production in visceral adipose tissue (VAT) mesenchymal stromal cells.
- It preserves ST2+ regulatory T cells in VAT, which are crucial for immunomodulation.
- These changes reduce adipose tissue inflammation and upregulate thermogenic genes in subcutaneous fat.
- The effects lead to better glucose tolerance, increased energy expenditure, without affecting food intake or muscle mass.