Human NLRP3 inflammasome activation leads to formation of condensate at the microtubule organizing center - PubMed
6 hours ago
- #Inflammasome
- #Cryo-ET
- #Pyroptosis
- NLRP3 inflammasome activation leads to condensate formation at the microtubule organizing center (MTOC).
- Advanced imaging techniques reveal NLRP3-associated vesicles transporting to the MTOC, Golgi dispersion, and mitochondrial damage during activation.
- The study links NLRP3 inflammasome activity to pyroptosis and autophagy, with implications for human inflammatory diseases.