Nomogram model for predicting incomplete immune reconstitution in people living with HIV based on clinical characteristics - PubMed
5 hours ago
- #immune reconstitution
- #HIV
- #nomogram
- Nomogram model developed to predict incomplete immune reconstitution (INR) in people living with HIV (PLWH).
- Study aims to identify INR risk early based on diagnostic criteria from the 2023 consensus in China.
- Retrospective study with primary cohort of 615 PLWH from Zhongnan Hospital and external validation set of 213 PLWH from Xishui County People's Hospital.
- LASSO and multivariable logistic regression identified baseline CD4+ T cell count, age at ART initiation, and AST level as independent predictors of INR.
- Nomogram demonstrated high AUC values (0.896, 0.903, 0.766) in training, internal validation, and external validation sets, respectively.
- Model shows satisfactory consistency and clinical utility, aiding individualized management for better patient prognosis.