Spatiotemporal Sequential Delivery of Chidamide Regulates Macrophage Reprogramming in Lymphoma Microenvironment Through HDACs-STAT3 Pathway - PubMed
6 hours ago
- #macrophage reprogramming
- #targeted drug delivery
- #lymphoma
- HDACs-induced STAT3 deacetylation drives M2 macrophage accumulation in diffuse large B-cell lymphoma (DLBCL), contributing to an immunosuppressive microenvironment.
- A novel targeted delivery system (Chid@M2pep-EVs) uses peptide-modified extracellular vesicles and pH-responsive hydrogel to spatiotemporally release chidamide specifically to M2 macrophages in the acidic lymphoma microenvironment.
- Chidamide inhibits HDACs, enhances STAT3 acetylation, and reprograms M2 macrophages to M1 phenotype, suppressing lymphoma growth in vivo with reduced dosage and adverse effects.